SIBUTROS

<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 150%; vertical-align: baseline;"><span style="font-size: 9pt; line-height: 150%; font-family: Verdana, sans-serif; letter-spacing: 0.4pt;" lang="EN-US">Sibutramine is a non-steroidal anorexigenic drug that enhances the feeling of satiety. The drug is a direct serotonin and norepinephrine reuptake inhibitor, structurally similar to amphetamine. It belongs to a group of drugs for the treatment of obesity and is used in a comprehensive maintenance treatment of patients with overweight. &nbsp;Sibutramine hydrochloride appeared on the market in 1998 under the brand name Meridia from the Abbot Laboratories Company.</span></p>

<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 150%; vertical-align: baseline;"><span style="font-size: 9pt; line-height: 150%; font-family: Verdana, sans-serif; letter-spacing: 0.4pt;" lang="EN-US">&nbsp;</span><span style="font-family: Verdana, sans-serif; font-size: 9pt; letter-spacing: 0.4pt; line-height: 150%;">Sibutramine acts in two ways:&nbsp;</span></p>

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<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 150%; vertical-align: baseline;"><span style="font-size: 9pt; line-height: 150%; font-family: Verdana, sans-serif;" lang="EN-US">1. Inhibits the reuptake of neurotransmitters serotonin and norepinephrine from synoptic gap, which reduces appetite and food intake (increases the feeling of satiety). In studies subjected patients reduced the daily ration by 1,300 calories.</span></p>

<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 150%; vertical-align: baseline;"><span style="font-size: 9pt; line-height: 150%; font-family: Verdana, sans-serif;" lang="EN-US">2. Stimulates metabolism and increases thermogenesis. This fat burning effect occurs due to the indirect impact on beta-3-adrenoreceptors, which are responsible for fat burning.&nbsp;</span></p>

<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 150%; vertical-align: baseline;"><span style="font-size: 9pt; line-height: 150%; font-family: Verdana, sans-serif; letter-spacing: 0.4pt;" lang="EN-US">Sibutramine converts by the liver into metabolites that significantly surpass sibutramine itself&nbsp; in the ability to inhibit serotonin and norepinephrine reuptake.</span></p>

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<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: 150%;"><span style="font-size: 9pt; line-height: 150%; font-family: Verdana, sans-serif; letter-spacing: 0.4pt;" lang="EN-US">&nbsp;</span></p>